Acid sphingomyelinase inhibition improves motor behavioral deficits and neuronal loss in an amyotrophic lateral sclerosis mouse model.
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ABSTRACT:
SUBMITTER: Choi BJ
PROVIDER: S-EPMC9813424 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
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Acid sphingomyelinase inhibition improves motor behavioral deficits and neuronal loss in an amyotrophic lateral sclerosis mouse model.
Choi Byung Jo BJ Park Kang Ho KH Park Min Hee MH Huang Eric Jinsheng EJ Kim Seung Hyun SH Bae Jae-Sung JS Jin Hee Kyung HK
BMB reports 20221201 12
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease characterized by the degeneration of motor neurons in the spinal cord. Main symptoms are manifested as weakness, muscle loss, and muscle atrophy. Some studies have reported that alterations in sphingolipid metabolism may be intimately related to neurodegenerative diseases, including ALS. Acid sphingomyelinase (ASM), a sphingolipid-metabolizing enzyme, is considered an important mediator of neurodegenerative diseases. H ...[more]
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