Prolactin in relation to gestational diabetes and metabolic risk in pregnancy and postpartum: A systematic review and meta-analysis.

ABSTRACT:

Context

Pre-clinical evidence suggests that prolactin has important metabolic functions in pregnancy and postpartum, in addition to lactogenic actions.

Objective

To explore the relationship between prolactin and maternal metabolic outcomes in human pregnancy and postpartum, particularly in relation to gestational diabetes mellitus (GDM).

Data sources

MEDLINE via OVID, CINAHL plus, Embase.

Study selection

Eligible studies included women who were pregnant or up to 12 months postpartum, reporting at least one maternal serum prolactin level in relation to key metabolic outcomes including GDM, glycaemic parameters, obesity, and gestational weight gain.

Data extraction

Two independent reviewers extracted data.

Data synthesis

Twenty-six articles w

SUBMITTER: Rassie K 

PROVIDER: S-EPMC9813437 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature