Untargeted metabolomics reveals gender- and age- independent metabolic changes of type 1 diabetes in Chinese children.

ABSTRACT:

Introduction

Type 1 diabetes (T1D) is a chronic condition associated with multiple complications that substantially affect both the quality of life and the life-span of children. Untargeted Metabolomics has provided new insights into disease pathogenesis and risk assessment.

Methods

In this study, we characterized the serum metabolic profiles of 76 children with T1D and 65 gender- and age- matched healthy controls using gas chromatography coupled with timeof-flight mass spectrometry. In parallel, we comprehensively evaluated the clinical phenome of T1D patients, including routine blood and urine tests, and concentrations of cytokines, hormones, proteins, and trace elements.

Results

A total of 70 differential metabolites covering 11 metabolic pathways associated with T

SUBMITTER: Zhang J 

PROVIDER: S-EPMC9813493 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature