Melanin nanoparticles alleviate sepsis-induced myocardial injury by suppressing ferroptosis and inflammation.

ABSTRACT: Myocardial injury as one of the severe complications leads to the increasing morbidity and mortality in patients with sepsis. Recent studies reported that reactive oxygen species (ROS)-mediated ferroptosis plays a critical role in the development of heart diseases. Therefore, we hypothesized that anti-ferroptosis agent might be a novel potential therapeutic strategy for sepsis-induced cardiac injury. Herein, we demonstrated that a small biocompatible and MRI-visible melanin nanoparticles (MMPP) improves myocardial function by inhibiting ROS-related ferroptosis signaling pathway. In LPS-induced murine sepsis model, after a single dose intravenously injection of MMPP treatment, MMPP markedly alleviated the myocardial injury including cardiac function and heart structure disorder through supp

SUBMITTER: Liu C 

PROVIDER: S-EPMC9813528 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature