Improving NK cell function in multiple myeloma with NKTR-255, a novel polymer-conjugated human IL-15.

ABSTRACT: Multiple myeloma (MM) is characterized by an immunosuppressive microenvironment that enables tumor development. One of the mechanisms of immune evasion used by MM cells is the inhibition of natural killer (NK) cell effector functions; thus, the restoration of NK cell antitumor activity represents a key goal to increase tumor cell recognition, avoid tumor escape and potentially enhancing the effect of other drugs. In this study, we evaluated the ability of the investigational medicine NKTR-255, an IL-15 receptor agonist, to engage the IL-15 pathway and stimulate NK cells against MM cells. We observed that incubation with NKTR-255 was able to tilt the balance toward an activated phenotype in NK cells isolated from peripheral blood mononuclear cells of patients with MM, with increased express

SUBMITTER: Fernandez RA 

PROVIDER: S-EPMC9813531 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature