Ferroptosis is critical for phthalates driving the blood-testis barrier dysfunction via targeting transferrin receptor.

ABSTRACT: The global rate of human male infertility is rising at an alarming rate owing to environmental and lifestyle changes. Phthalates are the most hazardous chemical additives in plastics and have an apparently negative impact on the function of male reproductive system. Ferroptosis is a recently described form of iron-dependent cell death and has been linked to several diseases. Transferrin receptor (TfRC), a specific ferroptosis marker, is a universal iron importer for all cells using extracellular transferrin. We aim to investigate the potential involvement of ferroptosis during male reproductive toxicity, and provide means for drawing conclusions on the effect of ferroptosis in phthalates-induced male reproductive disease. In this study, we found that di (2-ethylhexyl) phthalate (DEHP) trig

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC9813583 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature