Deletion of the Alzheimer's disease risk gene Abi3 locus results in obesity and systemic metabolic disruption in mice.

ABSTRACT: Alzheimer's disease (AD) genetics studies have identified a coding variant within ABI3 gene that increases the risk of developing AD. Recently, we demonstrated that deletion of the Abi3 gene locus dramatically exacerbates AD neuropathology in a transgenic mouse model of amyloidosis. In the course of this AD project, we unexpectedly found that deletion of the Abi3 gene locus resulted in a dramatic obese phenotype in non-transgenic mice. Here, we report our investigation into this serendipitous metabolic finding. Specifically, we demonstrate that mice with deletion of the Abi3 gene locus (Abi3^-/- ) have dramatically increased body weight and body fat. Further, we determined that Abi3^-/- mice have impaired energy expenditure. Add

SUBMITTER: Smith DC 

PROVIDER: S-EPMC9813750 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature