Dataset Information

The Gastric Cancer Registry: A Genomic Translational Resource for Multidisciplinary Research in Gastric Cancer.

ABSTRACT:

Background

Gastric cancer is a leading cause of cancer morbidity and mortality. Developing information systems which integrate clinical and genomic data may accelerate discoveries to improve cancer prevention, detection, and treatment. To support translational research in gastric cancer, we developed the Gastric Cancer Registry (GCR), a North American repository of clinical and cancer genomics data.

Methods

Participants self-enrolled online. Entry criteria into the GCR included the following: (i) diagnosis of gastric cancer, (ii) history of gastric cancer in a first- or second-degree relative, or (iii) known germline mutation in the gene CDH1. Participants provided demographic and clinical information through a detailed survey. Some participants provided specimens of saliva and tumor samples. Tumor samples underwent exome sequencing, whole-genome sequencing, and transcriptome sequencing.

Results

From 2011 to 2021, 567 individuals registered and returned the clinical questionnaire. For this cohort 65% had a personal history of gastric cancer, 36% reported a family history of gastric cancer, and 14% had a germline CDH1 mutation. 89 patients with gastric cancer provided tumor samples. For the initial study, 41 tumors were sequenced using next-generation sequencing. The data was analyzed for cancer mutations, copy-number variations, gene expression, microbiome, neoantigens, immune infiltrates, and other features. We developed a searchable, web-based interface (the GCR Genome Explorer) to enable researchers' access to these datasets.

Conclusions

The GCR is a unique, North American gastric cancer registry which integrates clinical and genomic annotation.

Impact

Available for researchers through an open access, web-based explorer, the GCR Genome Explorer will accelerate collaborative gastric cancer research across the United States and world.

SUBMITTER: Almeda AF

PROVIDER: S-EPMC9813806 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Publications

The Gastric Cancer Registry: A Genomic Translational Resource for Multidisciplinary Research in Gastric Cancer.

Almeda Alison F AF Grimes Susan M SM Lee HoJoon H Greer Stephanie S Shin GiWon G McNamara Madeline M Hooker Anna C AC Arce Maya M MM Kubit Matthew M Schauer Marie C MC Van Hummelen Paul P Ma Cindy C Mills Meredith A MA Huang Robert J RJ Hwang Joo Ha JH Amieva Manuel R MR Han Summer S SS Ford James M JM Ji Hanlee P HP

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20220901 9

<h4>Background</h4>Gastric cancer is a leading cause of cancer morbidity and mortality. Developing information systems which integrate clinical and genomic data may accelerate discoveries to improve cancer prevention, detection, and treatment. To support translational research in gastric cancer, we developed the Gastric Cancer Registry (GCR), a North American repository of clinical and cancer genomics data.<h4>Methods</h4>Participants self-enrolled online. Entry criteria into the GCR included th ...[more]

PMID: 35771165

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Dataset Information

The Gastric Cancer Registry: A Genomic Translational Resource for Multidisciplinary Research in Gastric Cancer.

Background

Methods

Results

Conclusions

Impact

Publications

The Gastric Cancer Registry: A Genomic Translational Resource for Multidisciplinary Research in Gastric Cancer.

Similar Datasets

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