IL-13/IL-4 signaling contributes to fibrotic progression of the myeloproliferative neoplasms.

ABSTRACT: Myelofibrosis (MF) is a disease associated with high unmet medical needs because allogeneic stem cell transplantation is not an option for most patients, and JAK inhibitors are generally effective for only 2 to 3 years and do not delay disease progression. MF is characterized by dysplastic megakaryocytic hyperplasia and progression to fulminant disease, which is associated with progressively increasing marrow fibrosis. Despite evidence that the inflammatory milieu in MF contributes to disease progression, the specific factors that promote megakaryocyte growth are poorly understood. Here, we analyzed changes in the cytokine profiles of MF mouse models before and after the development of fibrosis, coupled with the analysis of bone marrow populations using single-cell RNA sequencing. We found

SUBMITTER: Melo-Cardenas J 

PROVIDER: S-EPMC9813832 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature