Depressed Protein Synthesis and Anabolic Signaling Potentiate ACL Tear-Resultant Quadriceps Atrophy.

ABSTRACT:

Background

Anterior cruciate ligament (ACL) tear (ACLT) leads to protracted quadriceps muscle atrophy. Protein turnover largely dictates muscle size and is highly responsive to injury and loading. Regulation of quadriceps molecular protein synthetic machinery after ACLT has largely been unexplored, limiting development of targeted therapies.

Purpose

To define the effect of ACLT on (1) the activation of protein synthetic and catabolic signaling within quadriceps biopsy specimens from human participants and (2) the time course of alterations to protein synthesis and its molecular regulation in a mouse ACL injury model.

Study design

Descriptive laboratory study.

Methods

Muscle biopsy specimens were obtained from the ACL-injured and noninjured vastus lateralis of y

SUBMITTER: Keeble AR 

PROVIDER: S-EPMC9813974 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature