Subcortical shape in pediatric and adult obsessive-compulsive disorder.

ABSTRACT:

Background

Obsessive-compulsive disorder (OCD) implicates alterations in cortico-striato-thalamo-cortical and fronto-limbic circuits. Building on prior structural findings, this is the largest study to date examining subcortical surface morphometry in OCD.

Methods

Structural magnetic resonance imaging data were collected from 200 participants across development (5-55 years): 28 youth and 75 adults with OCD and 27 psychiatrically healthy youth and 70 adults. General linear models were used to assess group differences and group-by-age interactions on subcortical shape (FSL FIRST).

Results

Compared to healthy participants, those with OCD exhibited surface expansions on the right nucleus accumbens and inward left amygdala deformations, which were associated with greater O

SUBMITTER: Wang Z 

PROVIDER: S-EPMC9813975 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature