A general method for calculating power for GEE analysis of complete and incomplete stepped wedge cluster randomized trials.

ABSTRACT: Stepped wedge designs have uni-directional crossovers at randomly assigned time points (steps) where clusters switch from control to intervention condition. Incomplete stepped wedge designs are increasingly used in cluster randomized trials of health care interventions and have periods without data collection due to logistical, resource and patient-centered considerations. The development of sample size formulae for stepped wedge trials has primarily focused on complete designs and continuous responses. Addressing this gap, a general, fast, non-simulation based power procedure is proposed for generalized estimating equations analysis of complete and incomplete stepped wedge designs and its predicted power is compared to simulated power for binary and continuous responses. An extensive set

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9814029 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature