Comparing infrared spectroscopic methods for the characterization of Plasmodium falciparum-infected human erythrocytes.

ABSTRACT: Malaria, caused by parasites of the species Plasmodium, is among the major life-threatening diseases to afflict humanity. The infectious cycle of Plasmodium is very complex involving distinct life stages and transitions characterized by cellular and molecular alterations. Therefore, novel single-cell technologies are warranted to extract details pertinent to Plasmodium-host cell interactions and underpinning biological transformations. Herein, we tested two emerging spectroscopic approaches: (a) Optical Photothermal Infrared spectroscopy and (b) Atomic Force Microscopy combined with infrared spectroscopy in contrast to (c) Fourier Transform InfraRed microspectroscopy, to investigate Plasmodium-infected erythrocytes. Chemical spatial distributions of selected bands and spectra captured usin

SUBMITTER: Banas AM 

PROVIDER: S-EPMC9814045 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature