Application of Defined Approaches to Assess Skin Sensitization Potency of Isothiazolinone Compounds.

ABSTRACT:

Introduction

Isothiazolinones (ITs) are widely used as antimicrobial preservatives in cosmetics and as additives for preservation of consumer and industrial products to control bacteria, fungi, and algae. Although they are effective biocides, they have the potential to produce skin irritation and sensitization, which poses a human health hazard. In this project, we evaluated nonanimal defined approaches (DAs) for skin sensitization that can provide point-of-departure estimates for use in quantitative risk assessment for ITs.

Materials and methods

The skin sensitization potential of six ITs was evaluated using three internationally harmonized nonanimal test methods: the direct peptide reactivity assay, KeratinoSens™, and the human cell line activation test. Results from these

SUBMITTER: Strickland J 

PROVIDER: S-EPMC9814110 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature