Altered gut microbiomes are associated with the symptomatic status of unruptured intracranial aneurysms.

ABSTRACT:

Background

Gut microbiome has recently been recognized as an important environmental factor affecting the occurrence and development of unruptured intracranial aneurysms (UIA). This study aimed to investigate the relationship between gut microbiome and symptomatic UIA, which is a predictor of instability and a high propensity to rupture.

Methods

A total of 132 patients including 86 asymptomatic UIA and 46 symptomatic UIA were recruited in the study. The composition of gut bacterial communities was determined by 16S ribosomal RNA gene sequencing. In addition, Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) was used to predict the functional composition of the gut microbiome.

Results

There is no difference in the fecal microbia

SUBMITTER: Sun K 

PROVIDER: S-EPMC9814123 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature