Genome-wide methylation profiling identifies a novel gene signature for patients with synchronous colorectal cancer.

ABSTRACT:

Background

There are no robust tools for the diagnosis of synchronous colorectal cancer (SyCRC). Herein, we developed the first methylation signature to identify and characterise patients with SyCRC.

Methods

For biomarker discovery, we analysed the genome-wide methylation profiles of 16 SyCRC and 18 solitary colorectal cancer (SoCRC) specimens. We thereafter established a methylation signature risk-scoring model to identify SyCRC in an independent cohort of 38 SyCRC and 42 SoCRC patients. In addition, we evaluated the prognostic value of the identified methylation profile.

Results

We identified six differentially methylated CpG probes/sites that distinguished SyCRC from SoCRC. In the validation cohort, we developed a methylation panel that identified patients with SyC

SUBMITTER: Okada Y 

PROVIDER: S-EPMC9814149 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature