MiRNAs from serum-derived extracellular vesicles as biomarkers for uveal melanoma progression.

ABSTRACT: Uveal melanoma (UM) is a rare type of malignancy that originates from melanocytes in the choroid, iris and the eye's ciliary body. Biomarkers for early detection and progression of UM, especially the molecular traits governing the development of metastasis, are still not available in clinical practice. One extensively studied components of liquid biopsies are extracellular vesicles. Due to their unique molecular cargo, they can contribute to early cancer development and at the same time carry markers for disease onset and progression. For characterisation of the miRNA profiles present in circulating serum-derived exosomes of patients with diagnosed primary and metastatic UM, we have analyzed the miRNA cargos using next-generation sequencing followed by RT-qPCR validation in a cohort of pat

SUBMITTER: Wroblewska JP 

PROVIDER: S-EPMC9814164 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature