The gut microbiota in multiple sclerosis varies with disease activity.

ABSTRACT:

Background

Multiple sclerosis is a chronic immune-mediated disease of the brain and spinal cord resulting in physical and cognitive impairment in young adults. It is hypothesized that a disrupted bacterial and viral gut microbiota is a part of the pathogenesis mediating disease impact through an altered gut microbiota-brain axis. The aim of this study is to explore the characteristics of gut microbiota in multiple sclerosis and to associate it with disease variables, as the etiology of the disease remains only partially known.

Methods

Here, in a case-control setting involving 148 Danish cases with multiple sclerosis and 148 matched healthy control subjects, we performed shotgun sequencing of fecal microbial DNA and associated bacterial and viral microbiota findings with plas

SUBMITTER: Thirion F 

PROVIDER: S-EPMC9814178 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature