Acyl-chain saturation regulates the order of phosphatidylinositol 4,5-bisphosphate nanodomains.

ABSTRACT: Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P₂) plays a critical role in the regulation of various plasma membrane processes and signaling pathways in eukaryotes. A significant amount of cellular resources are spent on maintaining the dominant 1-stearoyl-2-arachidonyl PI(4,5)P₂ acyl-chain composition, while less abundant and more saturated species become more prevalent in response to specific stimuli, stress or aging. Here, we report the impact of acyl-chain structure on the biophysical properties of cation-induced PI(4,5)P₂ nanodomains. PI(4,5)P₂ species with increasing levels of acyl-chain saturation cluster in progressively more ordered nanodomains, culminating in the formation of gel-like nanodomains for fully saturated species. The formati

SUBMITTER: Borges-Araujo L 

PROVIDER: S-EPMC9814227 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature