Testosterone therapy and cancer risks among men in the SEER-Medicare linked database.

ABSTRACT:

Background

We examined associations between two forms of testosterone therapy (TT) and risks of seven cancers among men.

Methods

SEER-Medicare combines cancer registry data from the Surveillance, Epidemiology, and End Results programme with Medicare claims. Our population-based case-control study included incident cancer cases diagnosed between 1992-2015: prostate (n = 130,713), lung (n = 105,466), colorectal (n = 56,433), bladder (n = 38,873), non-Hodgkin lymphoma (n = 17,854), melanoma (n = 14,241), and oesophageal (n = 9116). We selected 100,000 controls from a 5% random sample of Medicare beneficiaries and used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI).

Results

TT was associated with lower risk of distant-stage prostate can

SUBMITTER: Butler EN 

PROVIDER: S-EPMC9814238 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature