Weight Gain Among Treatment-Naive Persons With HIV Receiving Dolutegravir in Kenya.

ABSTRACT:

Background

Several recent studies have linked integrase strand transfer inhibitors (INSTI) with increased weight gain.

Setting

The effects of sex on weight gain with dolutegravir (DTG)-based antiretroviral therapy (ART) among treatment-naïve participants in a lower-income, sub-Saharan population with high rates of pre-ART underweight and tuberculosis (TB) coinfection are unknown.

Methods

Our analysis included treatment-naïve participants in Kenya and starting their first treatment regimen between January 1, 2015, and September 30, 2018. Participants were grouped into 2 cohorts based on the initial treatment regimen [DTG vs. nonnucleoside reverse transcriptase inhibitors (NNRTI)]. We modelled weight changes over time using a multivariable nonlinear mixed-effect model,

SUBMITTER: Bourgi K 

PROVIDER: S-EPMC9814314 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature