The development of a cSMART-based integrated model for hepatocellular carcinoma diagnosis.

ABSTRACT: Hepatocellular carcinoma (HCC) generally arises from a background of liver cirrhosis (LC). Patients with cirrhosis and suspected HCC are recommended to undergo serum biomarker tests and imaging diagnostic evaluation. However, the performance of routine diagnostic methods in detecting early HCC remains unpromising. Here, we conducted a large-scale, multicenter study of 1675 participants including 490 healthy controls, 577 LC patients, and 608 HCC patients from nine clinical centers across nine provinces of China, profiled gene mutation signatures of cell-free DNA (cfDNA) using Circulating Single-Molecule Amplification and Resequencing Technology (cSMART) through detecting 931 mutation sites across 21 genes. An integrated diagnostic model called "Combined method" was developed by combining t

SUBMITTER: Wu T 

PROVIDER: S-EPMC9814336 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature