Flow parallel synthesizer for multiplex synthesis of aryl diazonium libraries via efficient parameter screening.

ABSTRACT: The development of miniaturized flow platforms would enable efficient and selective synthesis of drug and lead molecules by rapidly exploring synthetic methodologies and screening for optimal conditions, progress in which could be transformative for the field. In spite of tremendous advances made in continuous flow technology, these reported flow platforms are not devised to conduct many different reactions simultaneously. Herein, we report a metal-based flow parallel synthesizer that enables multiplex synthesis of libraries of compounds and efficient screening of parameters. This miniaturized synthesizer, equipped with a unique built-in flow distributor and n number of microreactors, can execute multiple types of reactions in parallel under diverse conditions, including photochemistry. Di

SUBMITTER: Ahn GN 

PROVIDER: S-EPMC9814388 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature