Combining visible-light induction and copper catalysis for chemo-selective nitrene transfer for late-stage amination of natural products.

ABSTRACT: Nitrene transfer chemistry is an effective strategy for introducing C-N bonds, which are ubiquitous in pharmaceuticals, agrochemicals and diverse bioactive natural products. The development of chemical methodology that can functionalize unique sites within natural products through nitrene transfer remains a challenge in the field. Herein, we developed copper catalyzed chemoselective allylic C-H amination and catalyst-free visible-light induced aziridination of alkenes through nitrene transfer. In general, both reactions tolerate a wide range of functional groups and occur with predictable regioselectivity. Furthermore, combination of these two methods enable the intermolecular chemo-selective late-stage amination of biologically active natural products, leading to C-H amination or C=C azir

SUBMITTER: Xing Q 

PROVIDER: S-EPMC9814389 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature