Association between psoriasis and lung cancer: two-sample Mendelian randomization analyses.

ABSTRACT:

Background

Observational studies reported an association between psoriasis and risk of lung cancer. However, whether psoriasis is causally associated with lung cancer is unclear.

Methods

Genetic summary data of psoriasis were retrieved from two independent genome-wide association studies (GWAS). Genetic information of lung cancer was retrieved from GWAS of International Lung Cancer Consortium. A set of quality control steps were conducted to select instrumental tools. We performed two independent two-sample Mendelian randomization (MR) analyses and a meta-analysis based on the two independent MR estimates to assess the causal relationship between psoriasis and lung cancer (LUCA) as well as its subtypes, squamous cell carcinoma (LUSC) and adenocarcinoma (LUAD).

Results

SUBMITTER: Wang X 

PROVIDER: S-EPMC9814449 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature