Survival outcomes of stage I colorectal cancer: development and validation of the ACEPLY model using two prospective cohorts.

ABSTRACT:

Background

Approximately 10% of stage I colorectal cancer (CRC) patients experience unfavorable clinical outcomes after surgery. However, little is known about the subset of stage I patients who are predisposed to high risk of recurrence or death. Previous evidence was limited by small sample sizes and lack of validation.

Methods

We aimed to identify early indicators and develop a risk stratification model to inform prognosis of stage I patients by employing two large prospective cohorts. Prognostic factors for stage II tumors, including T stage, number of nodes examined, preoperative carcinoma embryonic antigen (CEA), lymphovascular invasion, perineural invasion (PNI), and tumor grade were investigated in the discovery cohort, and significant findings were further validated

SUBMITTER: Wu Q 

PROVIDER: S-EPMC9814451 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature