Nrf2 is predominantly expressed in hippocampal neurons in a rat model of temporal lobe epilepsy.

ABSTRACT:

Background

Drug resistance is a particular problem in patients with temporal lobe epilepsy, where seizures originate mainly from the hippocampus. Many of these epilepsies are acquired conditions following an insult to the brain such as a prolonged seizure. Such conditions are characterized by pathophysiological mechanisms including massive oxidative stress that synergistically mediate the secondary brain damage, contributing to the development of epilepsy. The transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2) has emerged in recent years as an attractive therapeutic approach targeting to upregulate the antioxidative defenses in the cell, to ameliorate the oxidative stress-induced damage. Thus, it is important to understand the characteristics of Nrf2 activation

SUBMITTER: Sandouka S 

PROVIDER: S-EPMC9814517 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature