Specific and nondisruptive interaction of guanidium-functionalized gold nanoparticles with neutral phospholipid bilayers.

ABSTRACT: Understanding and controlling the interaction between nanoparticles and biological entities is fundamental to the development of nanomedicine applications. In particular, the possibility to realize nanoparticles capable of directly targeting neutral lipid membranes would be advantageous to numerous applications aiming at delivering nanoparticles and their cargos into cells and biological vesicles. Here, we use experimental and computational methodologies to analyze the interaction between liposomes and gold nanoparticles (AuNPs) featuring cationic headgroups in their protecting monolayer. We find that in contrast to nanoparticles decorated with other positively charged headgroups, guanidinium-coated AuNPs can bind to neutral phosphatidylcholine liposomes, inducing nondisruptive membrane pe

SUBMITTER: Morillas-Becerril L 

PROVIDER: S-EPMC9814519 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature