Quasi-continuous production of highly hyperpolarized carbon-13 contrast agents every 15 seconds within an MRI system.

ABSTRACT: Hyperpolarized contrast agents (HyCAs) have enabled unprecedented magnetic resonance imaging (MRI) of metabolism and pH in vivo. Producing HyCAs with currently available methods, however, is typically time and cost intensive. Here, we show virtually-continuous production of HyCAs using parahydrogen-induced polarization (PHIP), without stand-alone polarizer, but using a system integrated in an MRI instead. Polarization of ≈2% for [1-¹³C]succinate-d₂ or ≈19% for hydroxyethyl-[1-¹³C]propionate-d₃ was created every 15 s, for which fast, effective, and well-synchronized cycling of chemicals and reactions in conjunction with efficient spin-order transfer was key. We addressed these challenges using a dedicated, high-pressure, high-temperature reactor w

SUBMITTER: Schmidt AB 

PROVIDER: S-EPMC9814607 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature