Integrated analysis of necroptosis-related genes for evaluating immune infiltration and colon cancer prognosis.

ABSTRACT:

Background

Colon cancer (CC) is the second most common gastrointestinal malignancy. About one in five patients have already developed distant metastases at the time of initial diagnosis, and up to half of patients develop distant metastases from initial local disease, which leads to a poor prognosis for CC patients. Necroptosis plays a key role in promoting tumor growth in different tumors. The purpose of this study was to construct a prognostic model composed of necroptosis-related genes (NRGs) in CC.

Methods

The Cancer Genome Atlas was used to obtain information on clinical features and gene expression. Gene expression differential analysis, weighted gene co-expression network analysis, univariate Cox regression analysis and the least absolute shrinkage and selection opera

SUBMITTER: Yang W 

PROVIDER: S-EPMC9814966 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature