Catalyst-controlled oligomerization for the collective synthesis of polypyrroloindoline natural products.

ABSTRACT: In nature, many organisms generate large families of natural product metabolites that have related molecular structures as a means to increase functional diversity and gain an evolutionary advantage against competing systems within the same environment. One pathway commonly employed by living systems to generate these large classes of structurally related families is oligomerization, wherein a series of enzymatically catalysed reactions is employed to generate secondary metabolites by iteratively appending monomers to a growing serial oligomer chain. The polypyrroloindolines are an interesting class of oligomeric natural products that consist of multiple cyclotryptamine subunits. Herein we describe an iterative application of asymmetric copper catalysis towards the synthesis of six distinc

SUBMITTER: Jamison CR 

PROVIDER: S-EPMC9815142 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature