Early transient dysautonomia predicts the risk of infantile epileptic spasm syndrome onset: A prospective cohort study.

ABSTRACT:

Background

Infantile epileptic spasm syndrome (IESS) is an age-dependent epileptic encephalopathy with a significant risk of developmental regression. This study investigates the association between heart rate variability (HRV) in infants at risk of IESS and the clinical onset of IESS.

Methods

Sixty neonates at risk of IESS were prospectively followed from birth to 12 months with simultaneous electroencephalogram (EEG) and electrocardiogram recordings for 60 min at every 2-month interval. HRV metrics were calculated from 5 min time-epoch during sleep including frequency domain measures, Poincare analysis including cardiac vagal index (CVI) and cardiac sympathetic index (CSI), and detrended fluctuation analysis (DFA α1, DFA α2). To assess the effect of each HRV metric at the

SUBMITTER: Goswami I 

PROVIDER: S-EPMC9815183 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature