Temporal dynamics of the bat wing transcriptome: Insight into gene-expression changes that enable protection against pathogen.

ABSTRACT: Skin acts as a mechanical barrier between the body and its surrounding environment and plays an important role in resistance to pathogens. However, we still know little regarding skin responses to physiological changes, particularly with regard to responses against potential pathogens. We herein executed RNA-seq on the wing of the Rhinolophus ferrumequinum to assess gene-expression variations at four physiological stages: pre-hibernation, hibernation (early-hibernation and late-hibernation), and post-hibernation, as well as the gene-expression patterns of infected and uninfected bats with the Pseudogymnoascus destructans (Pd). Our results showed that a greater number of differentially expressed genes between the more disparate physiological stages. Functional enrichmen

SUBMITTER: Li A 

PROVIDER: S-EPMC9815227 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature