Behavioral profiling of SLC38A10 knockout mice using the multivariate concentric square field^TM test.

ABSTRACT:

Introduction

SLC38A10 is a gene that encodes the SLC38A10 protein, also known as SNAT10. The SLC38 family is evolutionary old, and SLC38A10 is one of the oldest members of the family. It is ubiquitously expressed, and its substrates are glutamine, glutamate, alanine, aspartate, and serine. However, little is known about its biological importance.

Methods

In the current study, an SLC38A10 knockout mouse was run in the multivariate concentric square field ^TM (MCSF) test. The MCSF test gives the mouse a choice of areas to explore; sheltered areas, elevated and illuminated areas, or open spaces, and a behavioral profile is obtained. The multivariate data obtained were analyzed (i) for each parameter, (ii) parameters grouped into functional categories, and (iii)

SUBMITTER: Lindberg FA 

PROVIDER: S-EPMC9815452 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature