Resolving drug selection and migration in an inbred South American Plasmodium falciparum population with identity-by-descent analysis.

ABSTRACT: The human malaria parasite Plasmodium falciparum is globally widespread, but its prevalence varies significantly between and even within countries. Most population genetic studies in P. falciparum focus on regions of high transmission where parasite populations are large and genetically diverse, such as sub-Saharan Africa. Understanding population dynamics in low transmission settings, however, is of particular importance as these are often where drug resistance first evolves. Here, we use the Pacific Coast of Colombia and Ecuador as a model for understanding the population structure and evolution of Plasmodium parasites in small populations harboring less genetic diversity. The combination of low transmission and a high proportion of monoclonal infections means there are few outcrossing e

SUBMITTER: Carrasquilla M 

PROVIDER: S-EPMC9815574 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature