Publication bias in trials registered in the Australian New Zealand Clinical Trials Registry: Is it a problem? A cross-sectional study.

ABSTRACT:

Background

Timely publication of clinical trials is critical to ensure the dissemination and implementation of high-quality healthcare evidence. This study investigates the publication rate and time to publication of randomized controlled trials (RCTs) registered in the Australian New Zealand Clinical Trials Registry (ANZCTR).

Materials and methods

We conducted a cross-sectional study of RCTs registered with the ANZCTR in 2007, 2009, and 2011. Multiple bibliographic databases were searched until October 2021 to identify trial publications. We then calculated publication rates, proportions, and the time to publish calculated from the date of first participation enrolment to publication date.

Results

Of 1,970 trial registrations, 541 (27%) remained unpublished 10 to 14

SUBMITTER: Showell M 

PROVIDER: S-EPMC9815633 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature