Landscape of helper and regulatory antitumour CD4⁺ T cells in melanoma.

ABSTRACT: Within the tumour microenvironment, CD4⁺ T cells can promote or suppress antitumour responses through the recognition of antigens presented by human leukocyte antigen (HLA) class II molecules^1,2, but how cancers co-opt these physiologic processes to achieve immune evasion remains incompletely understood. Here we performed in-depth analysis of the phenotype and tumour specificity of CD4⁺ T cells infiltrating human melanoma specimens, finding that exhausted cytotoxic CD4⁺ T cells could be directly induced by melanoma cells through recognition of HLA class II-restricted neoantigens, and also HLA class I-restricted tumour-associated antigens. CD4⁺ T regulatory (T_Reg) cells could be indirectly elicited through presentation of tum

SUBMITTER: Oliveira G 

PROVIDER: S-EPMC9815755 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature