Metrics of high cofluctuation and entropy to describe control of cardiac function in the stellate ganglion.

ABSTRACT: Stellate ganglia within the intrathoracic cardiac control system receive and integrate central, peripheral, and cardiopulmonary information to produce postganglionic cardiac sympathetic inputs. Pathological anatomical and structural remodeling occurs within the neurons of the stellate ganglion (SG) in the setting of heart failure (HF). A large proportion of SG neurons function as interneurons whose networking capabilities are largely unknown. Current therapies are limited to targeting sympathetic activity at the cardiac level or surgical interventions such as stellectomy, to treat HF. Future therapies that target the SG will require understanding of their networking capabilities to modify any pathological remodeling. We observe SG networking by examining cofluctuation and specificity of SG

SUBMITTER: Gurel NZ 

PROVIDER: S-EPMC9815826 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature