Expanding repertoire of SARS-CoV-2 deletion mutations contributes to evolution of highly transmissible variants.

ABSTRACT: The emergence of highly transmissible SARS-CoV-2 variants and vaccine breakthrough infections globally mandated the characterization of the immuno-evasive features of SARS-CoV-2. Here, we systematically analyzed 2.13 million SARS-CoV-2 genomes from 188 countries/territories (up to June 2021) and performed whole-genome viral sequencing from 102 COVID-19 patients, including 43 vaccine breakthrough infections. We identified 92 Spike protein mutations that increased in prevalence during at least one surge in SARS-CoV-2 test positivity in any country over a 3-month window. Deletions in the Spike protein N-terminal domain were highly enriched for these 'surge-associated mutations' (Odds Ratio = 14.19, 95% CI 6.15-32.75, p value = 3.41 × 10^-10). Based on a longitudinal analysis of muta

SUBMITTER: Venkatakrishnan AJ 

PROVIDER: S-EPMC9815892 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature