Deterioration of Phosphate Homeostasis Is a Trigger for Cardiac Afterload　- Clinical Importance of Fibroblast Growth Factor 23 for Accelerated Aging.

ABSTRACT: Background: After the discovery of the Klotho gene, phosphate came into focus as a pathogenetic aging agent. Phosphate homeostasis is controlled by phosphate-regulating hormones: fibroblast growth factor 23 (FGF23), vitamin D₃, and parathyroid hormone. This study investigated the relationship between the deterioration in phosphate homeostasis and arterial stiffness by measuring serum FGF23 concentrations. Methods and Results: The study subjects comprised 82 hospitalized patients (31 males, 51 females; mean [±SD] age 78.6±10.5 years). All patients underwent chest computed tomography, measurement of central blood pressure (BP), and blood chemistry tests. Arterial calcification and/or stiffness was evaluated using the Agatston calcification score (ACS) a

SUBMITTER: Mizuno Y 

PROVIDER: S-EPMC9815959 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature