An updated meta-analysis of device related thrombus following left atrial appendage closure in patients with atrial fibrillation.

ABSTRACT:

Aims

Device related thrombus (DRT) is a known complication of left atrial appendage closure (LAAC). However, the relation between DRT and elevated risk of ischemic events remains controversial. This study is sought to reassessed the incidence of DRT following LAAC and the relation between DRT and elevated risk of ischemic stroke and systemic embolism (SE) with latest clinical trials included.

Methods

The PubMed, Embase, and Cochrane Library databases were systematically searched from their inception until April 2022 for studies that reported the incidence of DRT and compared the incidence of both stroke and SE between DRT patients and non-DRT patients.

Results

In 59 eligible studies, the incidence of DRT was 366/12,845 (2.8%, ranging from 0 to 11%, I ²

SUBMITTER: Zhang S 

PROVIDER: S-EPMC9816128 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature