Curcuminoid supplementation in canine diabetic mellitus and its complications using proteomic analysis.

ABSTRACT:

Introduction

Inflammation and oxidative stress contribute to diabetes pathogenesis and consequences. Therapeutic approaches for canine diabetes remain a challenge. Curcumin has anti-inflammatory and anti-oxidative effects and is beneficial for humans with diabetes mellitus (DM); however, data on its impact on canine diabetes is limited. This study aimed to evaluate the potential for causing adverse effects, anti-inflammatory effects, anti-oxidative effects and proteomic patterns of curcuminoid supplementation on canine DM.

Methods

Altogether, 18 dogs were divided into two groups: DM (n = 6) and healthy (n = 12). Curcuminoid 250 mg was given to the DM group orally daily for 180 days. Blood and urine sample collection for hematological parameters, blood biochemis

SUBMITTER: Suemanotham N 

PROVIDER: S-EPMC9816143 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature