Characterisation of N-linked protein glycosylation in the bacterial pathogen Campylobacter hepaticus.

ABSTRACT: Campylobacter hepaticus is an important pathogen which causes Spotty Liver Disease (SLD) in layer chickens. SLD results in an increase in mortality and a significant decrease in egg production and therefore is an important economic concern of the global poultry industry. The human pathogen Campylobacter jejuni encodes an N-linked glycosylation system that plays fundamental roles in host colonization and pathogenicity. While N-linked glycosylation has been extensively studied in C. jejuni and is now known to occur in a range of Campylobacter species, little is known about C. hepaticus glycosylation. In this study glycoproteomic analysis was used to confirm the functionality of the C. hepaticus N-glycosylation system. It was shown that C. hepaticus HV10^T modifies > 35 proteins wit

SUBMITTER: McDonald JB 

PROVIDER: S-EPMC9816155 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature