Practical application of the interim internal threshold of toxicological concern (iTTC): a case study based on clinical data.

ABSTRACT: We present a case study that provides a practical step-by-step example of how the internal Threshold of Toxicological Concern (iTTC) can be used as a tool to refine a TTC-based assessment for dermal exposures to consumer products. The case study uses a theoretical scenario where there are no systemic toxicity data for the case study chemicals (avobenzone, oxybenzone, octocrylene, homosalate, octisalate, octinoxate, and ecamsule). Human dermal pharmacokinetic data following single and repeat dermal exposure to products containing the case study chemicals were obtained from data published by the US FDA. The clinical studies utilized an application procedure that followed maximal use conditions (product applied as 2 mg/cm² to 75% of the body surface area, 4 times a day). The case s

SUBMITTER: Najjar A 

PROVIDER: S-EPMC9816204 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature