Additive value of [¹⁸F]PI-2620 perfusion imaging in progressive supranuclear palsy and corticobasal syndrome.

ABSTRACT:

Purpose

Early after [¹⁸F]PI-2620 PET tracer administration, perfusion imaging has potential for regional assessment of neuronal injury in neurodegenerative diseases. This is while standard late-phase [¹⁸F]PI-2620 tau-PET is able to discriminate the 4-repeat tauopathies progressive supranuclear palsy and corticobasal syndrome (4RTs) from disease controls and healthy controls. Here, we investigated whether early-phase [¹⁸F]PI-2620 PET has an additive value for biomarker based evaluation of 4RTs.

Methods

Seventy-eight patients with 4RTs (71 ± 7 years, 39 female), 79 patients with other neurodegenerative diseases (67 ± 12 years, 35 female) and twelve age-matched controls (69 ± 8 years, 8 female) underwent dynamic (0-60 min) [¹⁸F]PI-262

SUBMITTER: Katzdobler S 

PROVIDER: S-EPMC9816230 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature