Combination of pre-treatment dynamic [¹⁸F]FET PET radiomics and conventional clinical parameters for the survival stratification in patients with IDH-wildtype glioblastoma.

ABSTRACT:

Purpose

The aim of this study was to build and evaluate a prediction model which incorporates clinical parameters and radiomic features extracted from static as well as dynamic [¹⁸F]FET PET for the survival stratification in patients with newly diagnosed IDH-wildtype glioblastoma.

Methods

A total of 141 patients with newly diagnosed IDH-wildtype glioblastoma and dynamic [¹⁸F]FET PET prior to surgical intervention were included. Patients with a survival time ≤ 12 months were classified as short-term survivors. First order, shape, and texture radiomic features were extracted from pre-treatment static (tumor-to-background ratio; TBR) and dynamic (time-to-peak; TTP) images, respectively, and randomly divided into a training (n = 99) and a testing cohort (n 

SUBMITTER: Li Z 

PROVIDER: S-EPMC9816231 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature