Flare on [¹⁸F]PSMA-1007 PET/CT after short-term androgen deprivation therapy and its correlation to FDG uptake: possible marker of tumor aggressiveness in treatment-naive metastatic prostate cancer patients.

ABSTRACT:

Purpose

Short-term androgen deprivation therapy (ADT) is known to increase heterogeneously prostate-specific membrane antigen (PSMA) expression. This phenomenon might indicate the potential of cancer lesions to respond to ADT. In this prospective study, we evaluated the flare on [¹⁸F]PSMA-1007 PET/CT after ADT in metastatic prostate cancer (PCa). Given that aggressive PCa tends to display FDG uptake, we particularly investigated whether the changes in PSMA uptake might correlate with glucose metabolism.

Methods

Twenty-five men with newly diagnosed treatment-naïve metastatic PCa were enrolled in this prospective registered clinical trial. All the patients underwent [¹⁸F]PSMA-1007 PET/CT immediately before and 3-4 weeks after ADT initiation (degarelix). B

SUBMITTER: Malaspina S 

PROVIDER: S-EPMC9816233 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature