Human biodistribution and radiation dosimetry of the demyelination tracer [¹⁸F]3F4AP.

ABSTRACT:

Purpose

[¹⁸F]3F4AP is a novel PET radiotracer that targets voltage-gated potassium (K⁺) channels and has shown promise for imaging demyelinated lesions in animal models of neurological diseases. This study aimed to evaluate the biodistribution, safety, and radiation dosimetry of [¹⁸F]3F4AP in healthy human volunteers.

Methods

Four healthy volunteers (2 females) underwent a 4-h dynamic PET scan from the cranial vertex to mid-thigh using multiple bed positions after administration of 368 ± 17.9 MBq (9.94 ± 0.48 mCi) of [¹⁸F]3F4AP. Volumes of interest for relevant organs were manually drawn guided by the CT, and PET images and time-activity curves (TACs) were extracted. Radiation dosimetry was estimated from the integrated TACs using

SUBMITTER: Brugarolas P 

PROVIDER: S-EPMC9816249 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature