Associations between saliva and plasma cytokines in cognitively normal, older adults.

ABSTRACT:

Background

Inflammatory responses play key roles in the development and progression of many pathological conditions, including neurodegenerative diseases. Accurate quantification of inflammatory factors in saliva would be highly advantageous, given its convenience and non-invasive nature, especially in elderly populations.

Methods

In this study, we measured levels of 10 cytokines, and the pro-inflammatory factor, YKL-40, in plasma and saliva samples from a cohort of nondemented older adults (n = 71; 62% female; 70.3 ± 6.4 years) using sensitive electrochemiluminescence-based immunoassays.

Results

We found that the mean levels of all cytokines were higher in saliva compared to plasma and that strong sex differences were observed for both saliva and plasma cytokines in

SUBMITTER: Parkin GM 

PROVIDER: S-EPMC9816252 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature