Radiogenomic markers enable risk stratification and inference of mutational pathway states in head and neck cancer.

ABSTRACT:

Purpose

Head and neck squamous cell carcinomas (HNSCCs) are a molecularly, histologically, and clinically heterogeneous set of tumors originating from the mucosal epithelium of the oral cavity, pharynx, and larynx. This heterogeneous nature of HNSCC is one of the main contributing factors to the lack of prognostic markers for personalized treatment. The aim of this study was to develop and identify multi-omics markers capable of improved risk stratification in this highly heterogeneous patient population.

Methods

In this retrospective study, we approached this issue by establishing radiogenomics markers to identify high-risk individuals in a cohort of 127 HNSCC patients. Hybrid in vivo imaging and whole-exome sequencing were employed to identify quantitative imaging markers

SUBMITTER: Spielvogel CP 

PROVIDER: S-EPMC9816299 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature